Reviewing -Gal in valve immunology

Reviewing α-Gal in valve immunology.

We thank Dr. Alhan et al. for their constructive and important comment on our study [1]. They highlighted some relevant limitations [2] of this small randomized trial which we aim to address in our response in part. Alhan et al. have correctly asked for some unreported preoperative factors such as the ejection fraction, the pre-OP medication, including angiotensin-converting enzyme inhibitors, ...

Mechanisms of Gal 1-3Gal 1-4GlcNAc-R ( Gal) expression on porcine valve endothelial cells

Results: Porcine valvular endothelial cells grew rapidly on a gelatin substrate. Similar to our previous in vivo results, valve endothelial cells expressed Gal much less intensely than did aortic endothelial cells. Porcine aortic endothelial cells expressed an isolectin B4 (isolectin B4 lectin Bandeiraea simplicifolia) immunodetectable band at 135 kd that was not visible on porcine valve endoth...

Reviewing the nanotechnology in cosmeceuticals

Cosmeceuticals are the fastest growing segment of the personal care industry, and a number of topical cosmeceutical treatments for conditions such as photoaging, hyperpigmentation, wrinkles, and hair damage have come into widespread use. In the cosmeceutical arena nanotechnology has played an important role. Using new techniques to manipulate matter at an atomic or molecular level, opening up n...

Anti-Gal and Anti-Non Gal Antibody Barriers in Xenotransplantation

The many studies on the immune mechanisms contributing to xenograft rejection have identified two types of antibodies (Abs) that form barriers to transplantation of xenografts into humans: 1. Natural and induced anti-Gal Abs, and 2. Induced anti-non gal Abs. The formidable barrier of anti-Gal Abs seems to have been removed by the generation of 1,3galactosyltransferase (1,3GT) knockout (KO) pi...

Expression Profile of Galectins (Gal-1, Gal-9, Gal-11 and Gal-13) in Human Bone Marrow Derived Mesenchymal Stem Cells in Different Culture Mediums