Review: Protein-Protein Interactions: Methods and Applications
نویسندگان
چکیده
منابع مشابه
Discovering Domains Mediating Protein Interactions
Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
متن کامل[Methods for analysis of protein-protein and protein-ligand interactions].
In order to maintain cellular homeostasis, cellular proteins coexist in complex and variable molecular assemblies. Therefore, understanding of major physiological processes at molecular level is based on analysis of protein-protein interaction networks. Firstly, composition of the molecular assembly has to be qualitatively analyzed. In the next step, quantitative bio-chemical properties of the ...
متن کاملKernel methods for predicting protein-protein interactions
MOTIVATION Despite advances in high-throughput methods for discovering protein-protein interactions, the interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experimentalists in the search for novel interactions. RESULTS We present a kernel method for predicting protein-protein interactions usin...
متن کاملComputational methods for predicting protein-protein interactions.
Protein-protein interactions (PPIs) play a critical role in many cellular functions. A number of experimental techniques have been applied to discover PPIs; however, these techniques are expensive in terms of time, money, and expertise. There are also large discrepancies between the PPI data collected by the same or different techniques in the same organism. We therefore turn to computational t...
متن کاملOptical methods for measuring protein-protein interactions.
The hepatopancreas protein, therefore, probably represents the membranous proton channel of the vacuolar ATPase and electron microscopy has given us the clearest impression yet of its organization; an organization clearly consistent with the functional characteristics of the chloroplast ATPase-CF,, complex [22]. It is hoped that techniques such as electron diffraction may improve the structural...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2005
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr050520z