Review on sodium glucose co-transporter-2 inhibitors for treatment of type-2 diabetes mellitus
نویسندگان
چکیده
Sodium glucose transporter-2 inhibitors (SGLT2-i) are a class of medicine that have been recently acknowledged and approved for management Type-2 Diabetes Mellitus (T2DM). They distinct encouraging extra-pancreatic glucuretic role has clinically applied blood sugar management. Reports published multiple side effects including ketoacidosis & ketonuria induced by SGLT2-i. This endeavor delves into the pharmacokinetics SGLT-i agents, deliberates utility these drugs suggests steps to maximize safe use agents their diverse beneficial effects.
منابع مشابه
Sodium Glucose Co transporter 2 (SGLT2) Inhibitors: A New Sword for the Treatment of Type 2 Diabetes Mellitus
The low affinity sodium glucose cotransporter (SGLT2) plays a major role in physiology of glucose reabsorption from proximal part of kidney. Almost all glucose excreted through glomerular filtration, is reabsorbed via SGLT2 until blood glucose level reaches to its threshold value for glucose excretion i.e. ~180mg/dl. Increasing the glucose excretion by inhibiting the SGLT2 is the novel approach...
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ژورنال
عنوان ژورنال: GSC biological and pharmaceutical sciences
سال: 2022
ISSN: ['2581-3250']
DOI: https://doi.org/10.30574/gscbps.2022.20.3.0371