Review of Experimental Models of Schizophrenia

Schizophrenia is a severe psychiatric disease that has lifetime prevalence of 1% in most the populations studied. The neuropathology and psychopathology are still poorly understood. This attributed to paucity adequate animal models. disorder human brain. Consequently, potency models research limited certain aspects disease. One difficult modelling animals been lack clear explicit conceptual framework for this disorder. review discussed drug-induced such as Ketamine (NMDA receptor antagonist), Phencyclidine antagonist) etc. It also genetic which include but not susceptibility Genes, Neuregulin-1(NRG1), DAT gene, Zinc finger DHH-type3 containing 8 (ZDHHC8) Dysbindin. went further discuss fetal Schizophrenia, postweaning social isolation ended with In-Vitro use improve understanding neurochemical structural CNS changes precipitate development rather than focus on treating symptoms, prerequisite enable new more effective therapeutic strategies be developed. Because complexity ambiguity gene-gene gene-environment interactions aetiology schizophrenia, challenge developing reliable predictive disorder, likely through multiple early-life interventions, ongoing.