Review: mucolytic drugs reduce exacerbations, illness days, and antibiotic use in chronic bronchitis and chronic obstructive pulmonary disease
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چکیده
منابع مشابه
Review: mucolytic drugs reduce exacerbations, illness days, and antibiotic use in chronic bronchitis and COPD.
S t u d y s e l e c t i o n Studies were selected if they were randomized, double-blind, placebo-controlled trials of oral mucolytic drugs taken regularly for ≥ 2 months by adults who were > 20 years of age and had chronic bronchitis or COPD. Studies on inhaled mucolytic drugs, combinations of mucolytic drugs with antibiotics or bronchodilators, deoxyribonucleases, and such proteases as trypsin...
متن کاملMucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease.
BACKGROUND Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume and/or purulence of sputum and any therapy that reduced the number of exacerbations would be useful. There is a marked difference between countries in terms of the prescribing of mucolytics depending on whether or not they are perceived to ...
متن کاملOral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review.
OBJECTIVE To assess the effects of oral mucolytics in adults with stable chronic bronchitis and chronic obstructive pulmonary disease. DESIGN Systematic review of randomised controlled trials that compared at least two months of regular oral mucolytic drugs with placebo. STUDIES Twenty three randomised controlled trials in outpatients in Europe and United States. MAIN OUTCOME MEASURES Exa...
متن کاملMucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease.
BACKGROUND Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume or purulence of sputum, or both. Personal and healthcare costs associated with exacerbations indicate that any therapy that reduces the occurrence of exacerbations is useful. A marked difference among countries in terms of prescribing of mu...
متن کاملStatins and Pulmonary Hypertension in Chronic Obstructive Lung Disease
Chronic obstructive lung disease (COPD) is a chronic multisystem disease with a considerable burden. One of its most common complications is pulmonary artery hypertension (PAH). It has been demonstrated that the development of PAH is correlated with decreased quality of life and survival. Different medications have been proposed for the treatment of PAH, among which one can name statins. Howeve...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2002
ISSN: 1356-5524
DOI: 10.1136/ebm.7.2.53