Review: acellular vaccines prevent pertussis as effectively as whole-cell vaccines with fewer adverse events
نویسندگان
چکیده
منابع مشابه
Whole-cell and acellular pertussis vaccines.
OBJECTIVE To provide a review of pertussis vaccines, including information on efficacy, adverse reactions, and antibody production following administration of both whole-cell and acellular pertussis vaccines. DATA SOURCES A MEDLINE search and extensive review of journals was conducted to identify the information for this review. DATA EXTRACTION Pertinent studies reporting experience with pe...
متن کاملAcellular pertussis vaccines pertinent issues.
Efficacy of whole cell pertussis vaccines (wP) in humans correlates with (and hence is measured by) the ‘mouse protection test’, wherein vaccinated mice are challenged with live B. pertussis. This test does not work similarly with acellular pertussis vaccines (aP); hence antibody levels to various antigens are measured as a surrogate marker of efficacy. This difference between the direct as com...
متن کاملLimitations of acellular pertussis vaccines
Although humans are typically willing to punish so-called free riders—people who use public resources without contributing to them—most people balk at sanctioning community members who refuse to punish others. Modern societies usually address this threat to collective action by installing central authorities such as police and judicial systems that punish both free riders and individuals who re...
متن کاملAcellular and "low" pertussis vaccines: adverse events and the role of mutations.
OBJECTIVE to discuss the current PAHO recommendation that does not support the substitution of traditional cellular DTP vaccine by acellular DTP, and the role of mutations, in humans, as the main cause of rare adverse events, such as epileptic-like convulsions, triggered by pertussis vaccine. DATA REVIEW the main components related to toxic effects of cellular pertussis vaccines are the lipop...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2000
ISSN: 1356-5524
DOI: 10.1136/ebm.5.1.15