Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine

Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine

Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). We have previously shown that inactivation of the Escherichia coli cysB gene is the major cause of mecillinam resistance (MecR) in clinical isolates. In this study, we used different E. coli strains (laboratory and clinical isolates) that were MecR due to cysB mutations to determine h...

Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli

Thulin, E. 2017. Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1375. 69 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0090-0. The introduction of antibiotics in healthcare is one of the most important medical achievements with regard to reducing human morbidity and mortal...

Mecillinam Resistance in E. coli

Mecillinam – Reversion of Resistance and How to Test It

http://dx.doi.org/10.1016/j.ebiom.2017.08.023 2352-3964/© 2017 The Author. Published by Elsevier B.V Mecillinam (amdinocillin) is a penicillin produced by the Leo Pharthe clinician in choosing the correct treatment for the patients. For testmaceutical Company and marketed in 1976 (Lund & Tybring, 1972). It is available both in an i.v. and oral form, pivmecillinam. This antibiotic is an almost i...

[In-vitro activity of mecillinam against urine isolates of Escherichia coli from outpatient departments in Germany].

National and international guidelines recommend fosfomycin trometamol, nitrofurantoin, nitroxoline, and pivmecillinam as first-line agents for the treatment of acute uncomplicated cystitis. Escherichia coli is by far the leading cause of community-acquired urinary tract infections. Pivmecillinam (X-SYSTO®) is an oral prodrug of mecillinam, a penicillin derivative that was reintroduced to the Ge...