Retrovirus receptors

Retrovirus receptors

The cell surface receptors that act as portals of virus entry into animal cells have become a focus of renewed interest in recent years with the identification of receptor molecules (Wimmer, 1994). Genetic manipulation of receptor genes has enabled the mapping of virus-binding sites and of the normal functions of the receptors. Expression of human receptors in transgenic mice (e.g., for polio v...

Identification of receptors for pig endogenous retrovirus.

Xenotransplantation of porcine tissues has the potential to treat a wide variety of major health problems including organ failure and diabetes. Balanced against the potential benefits of xenotransplantation, however, is the risk of human infection with a porcine microorganism. In particular, the transmission of porcine endogenous retrovirus (PERV) is a major concern [Chapman, L. E. & Bloom, E. ...

Cell Entry and Exit of Porcine Endogenous Retrovirus A: Receptors and Release Inhibitor

Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field. The aim of this thesis is to gain a better understanding of PERV biology, so as to help assess and reduce the risk of PERV zoonosis. PERV subgroup A can enter human cells through two human PERV-A ...

Retrovirus budding.

The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as "late" or "L" domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Tyr-Pro-x-Leu (YPxL). A number of recent studies have demonstrated that L domain...

Feline Retrovirus Infections