منابع مشابه
Retrograde Transport Redux
Trafficking of trophic factors in axons can occur in a retrograde and anterograde direction. Recent findings bring further support for a vesicle-based process for retrograde transport but raise new questions that need to be pursued. Unraveling the exact mechanisms that account for retrograde transport of neurotrophins and their receptors will reveal the cellular requirements for propagating tro...
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Many chemotherapeutic regimens produce neutropenia, which predisposes to microbial infection. However, not all neutropenic individuals develop infections, so the ability to predict this outcome would be a powerful clinical tool. In this issue of the JCI, Malka et al. describe a dynamic system model of neutrophil bactericidal activity that confirms and extends the concept of critical neutrophil ...
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P,fl-Iminodipropionitrile (IDPN), a neurotoxin, causes redistribution of neurofilaments in axons followed by the development of proximal axonal swellings and, in chronic intoxication, a distal decrease in axonal caliber. The latter changes are caused by a selective impairment in the slow anterograde axonal transport of neurofilament proteins. To assess the role of retrograde axonal transport in...
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The transport properties of the leftin Phaseolus vulgaris leucoagglutinin (PHA-L) were tested h the frog central nervous system. After delivery of the lectin to the lower brainstem by iontophoresis, stained axons and axon terminals, as well as neurons with richly arborizing dendrites, were observed in different regions of the brain and spinal cord even far away from the site of application. The...
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Active transport along the axon is crucial to the neuron. Motor-driven transport supplies the distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded proteins. Microtubule motors also drive long-distance signaling along the axon via signaling endosomes. Although positive signaling initiated by neurotrophic factors has been well-studied, recent research has foc...
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ژورنال
عنوان ژورنال: Neuron
سال: 2003
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(03)00401-x