منابع مشابه
Retinoids and Retinal Diseases.
Recent progress in molecular understanding of the retinoid cycle in mammalian retina stems from painstaking biochemical reconstitution studies supported by natural or engineered animal models with known genetic lesions and studies of humans with specific genetic blinding diseases. Structural and membrane biology have been used to detect critical retinal enzymes and proteins and their substrates...
متن کاملRetinoids for treatment of retinal diseases.
Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has increased exponentially over the past decade. Substantial progress in human genetics has facilitated the identification of candidate genes and complex networks underlying inherited retinal diseases. Natural mutations in animal models that mimic human diseases have been characterized a...
متن کاملClinical Approaches of Retinal Diseases in Pregnancy
Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), ...
متن کاملCell based therapies in retinal diseases
Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...
متن کاملRetinoids in Oral Diseases: An Enigmatic Role in Chemoprevention
Carcinogenesis is a complex disease which involves environmental and genetic factors as a predisposing cause that bring alterations in the microstructure of the cell. Vitamin A is considered as an essential micronutrient whose role is extensively known in physiologic and elusive in pathological state associated with chemopreventive and therapeutic modalities. Retinoids, form of Vitamin A, have ...
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ژورنال
عنوان ژورنال: Annual Review of Vision Science
سال: 2016
ISSN: 2374-4642,2374-4650
DOI: 10.1146/annurev-vision-111815-114407