Retinoid metabolism in human leucocytes

Retinoid metabolism is altered in human and mouse cicatricial alopecia

C57BL/6 mice develop dermatitis and scarring alopecia resembling human cicatricial alopecias (CAs), particularly the central centrifugal CA (CCCA) type. To evaluate the role of retinoids in CA, the expression of retinoid metabolism components were examined in these mice with mild, moderate, or severe CA compared with hair cycle-matched mice with no disease. Two feeding studies were conducted wi...

Retinoid metabolism in the skin.

Oxidative metabolism in cord-blood polymorphonuclear leucocytes.

Polymorphonuclear leucocytes were isolated from cord-blood samples collected from healthy, term infants. Oxidative metabolism was assessed in these cells by hexose monophosphate shunt activity and chemiluminescence. Basal levels of oxidative metabolism were spontaneously increased in resting (nonphagocytic) cord-blood cells as compared to adult controls. As a response to phagocytosis, cord-bloo...

Retinoid Metabolism and Diabetes Mellitus

Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders. Given the special concern over the recent increase in the prevalence of diabetes worldwide, the role of retinoid metabolism on glucose metabol...

Retinoid metabolism in the rat small intestine.

Vitamin A (retinol) is essential for epithelial cell growth, differentiation and proliferation. The absorption of retinol occurs in the small intestine, and the metabolism of this vitamin is not well studied in this organ. The intestinal epithelium has a high rate of cell proliferation and differentiation, and the present study looked at the level of retinoids and metabolizing enzymes involved ...