Retinal pigment epithelium contains a distinctive strychnine-binding site
نویسندگان
چکیده
منابع مشابه
Bovine retinal pigment epithelium contains novel types of phospholipase A2.
We have recently demonstrated the presence of phospholipase A2 (PLA2) activity in cells from bovine retinal pigment epithelium (RPE) [Jacob et al. (1996) J. Biol. Chem. 271, 19209-19218]. We report here our results on the characterization of this RPE-PLA2 activity. We show that RPE probably contains two types of PLA2 enzyme, as indicated by the results obtained with different PLA2-active fracti...
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PURPOSE Generate site-specific somatic mutations selectively in the retinal pigment epithelium (RPE) in mice. METHODS A transgenic mouse line expressing the Cre recombinase under the control of the tyrosinase-related protein (TRP)-1 promoter was generated. The presence of Cre was determined by in situ hybridization, and Cre-mediated excision of DNA was analyzed by PCR and alkaline phosphatase...
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Background: PEDF has neurotrophic activity and interacts with PEDF-R, a membrane-linked lipase. Results: A PEDF-binding region of PEDF-R is required for PEDF-R enzymatic stimulation and peptides derived from this region block PEDF/PEDF-R-mediated retinal survival activities. Conclusions: A ligand binding domain is identified in PEDF-R, a critical receptor for PEDF’s survival activity. Significa...
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Objective(s):The aim of this study was to evaluate distribution and changes of glycoconjugates of retinal photoreceptors during both pre- and postnatal development. Materials and Methods: Tissue sections from days 15 to 20 of Wistar rat embryos and 1 to 12 postnatal days of rat newborns including developing eye were prepared for lectinhistochemistry technique. Horseradish peroxidase (HRP)-label...
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Antibody-mediated rejection is characterized by donor-specific antibody produced by B cells. However, to our knowledge, B cell invasion and antibody in the inflamed retina after transplantation of retinal pigment epithelial (RPE) cells has not been reported. To determine if RPE transplantation could be performed using allografts, we established in vivo immune rejection models with induced pluri...
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ژورنال
عنوان ژورنال: Neurochemical Research
سال: 1982
ISSN: 0364-3190,1573-6903
DOI: 10.1007/bf00965087