Retargeting Strategies for Oncolytic Herpes Simplex Viruses
نویسندگان
چکیده
منابع مشابه
Retargeting Strategies for Oncolytic Herpes Simplex Viruses
Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is of...
متن کاملRetargeting of Viruses to Generate Oncolytic Agents
Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modification of their tropism to specifically enter and replicate in such cells. This review aims to describe the transductional targeting strategies currently e...
متن کاملRetargeting of herpes simplex virus (HSV) vectors.
Gene therapy applications depend on vector delivery and gene expression in the appropriate target cell. Vector infection relies on the distribution of natural virus receptors that may either not be present on the desired target cell or distributed in a manner to give off-target gene expression. Some viruses display a very limited host range, while others, including herpes simplex virus (HSV), c...
متن کاملA Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells
The oncolytic herpes simplex virus (HSV) that has been approved for clinical practice and those HSVs in clinical trials are attenuated viruses, often with the neurovirulence gene γ134.5 and additional genes deleted. One strategy to engineer nonattenuated oncolytic HSVs consists of retargeting the viral tropism to a cancer-specific receptor of choice, exemplified by HER2 (human epidermal growth ...
متن کاملHerpes Simplex and Pseudorabies Viruses
many must be the result of using impure systems and of secondary effects or else they are the product of a multiplicity of phenomena with similar end results. Dr. Vilcek is a splitter; he gives the impression that no unifying principle exists in the interferon system, but that there are several physically diverse interferons produced by the same cell and that cells may be induced to produce the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2016
ISSN: 1999-4915
DOI: 10.3390/v8030063