Retargeting adenoviral vectors to improve gene transfer into tumors
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چکیده
منابع مشابه
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Suicide gene therapy has met limited success for the treatment of rat pituitary tumors. In order to determine the cause of primary pituitary tumor resistance to suicide gene therapy, we studied the transgene expression of an adenoviral (Ad.RSV.beta gal.nls) and a herpes simplex virus-derived (tsK/beta-gal) vector, both harboring the beta-galactosidase reporter gene in rat prolactinomas. Rats ca...
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The multilayered structure of the cerebral cortex has been studied in detail. Early-born neurons migrate into the inner layer and late-born neurons migrate into more superficial layers, thus establishing an inside-out gradient. The progenitor cells appear to acquire layer-specific properties at the time of neuronal birth; however, the molecular mechanisms of cell-fate acquisition are still uncl...
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BACKGROUND Efficient methods of introducing genes into myocardial cells must be developed before local somatic cell gene therapy can be implemented against myocardial disease. Although adenoviral (Ad5) vectors have been used to target rodent hearts and plasmid DNA has been directly injected into the myocardium of rats and dogs, the amounts of recombinant protein produced by these procedures hav...
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....................................................................................................................... 1 Introduction ............................................................................................................1 1.1 Adenoviral Vectors ...................................................................................................2 1.1.1 Adenovirus...
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Hemophilia is an inherited blood clotting disorder resulting from deficiency of blood coagulation factors. Current standard of care for hemophilia patients is frequent intravenous infusions of the missing coagulation factor. Gene therapy for hemophilia involves the introduction of a normal copy of the deficient coagulation factor gene thereby potentially offering a definitive cure for the bleed...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2010
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2010.78