Resurfacing damaged articular cartilage to restore compressive properties
نویسندگان
چکیده
منابع مشابه
Contribution of proteoglycan osmotic swelling pressure to the compressive properties of articular cartilage.
The negatively charged proteoglycans (PG) provide compressive resistance to articular cartilage by means of their fixed charge density (FCD) and high osmotic pressure (π(PG)), and the collagen network (CN) provides the restraining forces to counterbalance π(PG). Our objectives in this work were to: 1), account for collagen intrafibrillar water when transforming biochemical measurements into a F...
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Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are u...
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For this study, we hypothesized that the depth-dependent compressive equilibrium properties of articular cartilage are the inherent consequence of its depth-dependent composition, and not the result of depth-dependent material properties. To test this hypothesis, our recently developed fibril-reinforced poroviscoelastic swelling model was expanded to include the influence of intra- and extra-fi...
متن کاملImaging the Biomechanical Properties of Articular Cartilage
Function: The primary function of articular cartilage is mechanical: under load it must deform to distribute the load over a larger area so as to minimize stress in the underlying bone. In addition, articular cartilage must provide a very low friction surface for gliding when the joint is flexed so that articulating joints move freely. Lastly, it must carry out these two functions for a lifetim...
متن کاملVulnerability of the superficial zone of immature articular cartilage to compressive injury.
OBJECTIVE The zonal composition and functioning of adult articular cartilage causes depth-dependent responses to compressive injury. In immature cartilage, shear and compressive moduli as well as collagen and sulfated glycosaminoglycan (sGAG) content also vary with depth. However, there is little understanding of the depth-dependent damage caused by injury. Since injury to immature knee joints ...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2015
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2014.10.023