Results of Octaplex for reversal of warfarin anticoagulation in patients with hip fracture

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Preoperative warfarin reversal for early hip fracture surgery.

PURPOSE To evaluate our hospital protocol of low-dose vitamin K titration for preoperative warfarin reversal for early hip fracture surgery. METHODS Records of 16 men and 33 women aged 63 to 93 (mean, 81) years who were taking warfarin for atrial fibrillation (n=40), venous thromboembolism (n=9), cerebrovascular accident (n=3), and prosthetic heart valve (n=3) and underwent surgery for hip fr...

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Comparison of different warfarin reversal protocols on surgical delay and complication rate in hip fracture patients.

PURPOSE. To compare the effects of different warfarin reversal protocols on surgical delay and complication rate in hip fracture patients. METHODS. Records of 7 men and 17 women aged 68 to 93 (mean, 82) years who were on warfarin and underwent surgery for femoral neck fractures were reviewed. The time to surgery, complication rate, and mortality were recorded, as were the International Normalis...

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Budget Impact Analysis of Warfarin Reversal Therapies Among Hip Fracture Patients in Finland

BACKGROUND Hip fractures require operation within 36-48 h, and they are most common in the elderly. A high International Normalized Ratio should be corrected before surgery. In the current study, we analyzed the budget impact of various warfarin reversal approaches. METHODS Four reversal strategies were chosen for the budget impact analysis: the temporary withholding of warfarin, administrati...

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Prothrombin complex concentrates in warfarin anticoagulation reversal

Anticoagulation is very effective for primary and secondary prevention of thromboembolic events. However, questions persist about the risks and management of over-anticoagulation. The annual incidence of major bleeding in trials and cohort studies has been reported to be between 1.1% and 2.3% in patients treated with warfarin to achieve an international normalized ratio (INR) of 2.0 to 3.0. The...

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ژورنال

عنوان ژورنال: Canadian Journal of Surgery

سال: 2019

ISSN: 0008-428X

DOI: 10.1503/cjs.018017