Restless Legs Syndrome in Multiple Sclerosis: Risk factors and effect on sleep quality – a case-control study

Introduction: Previous studies suggested an association between MS and Restless Legs Syndrome (RLS). Data on the prevalence of RLS in Austrian patients influence disease-modifying therapies (DMT) are lacking.Objective: To investigate (1) Austria compared to control persons (CP), (2) risk factors for MS, (3) DMTs and/or severity.Methods: Adult CP were screened by face-to-face interviews, including questionnaires severity, sleep quality daytime sleepiness.Results: 23.9% (n=117) had 3.4% (p<0.001) (n=119). The MS+RLS group (n=28) a higher rate impairment (78.6% vs 21.3%, p<0.001) excessive sleepiness (32.1% 15.7%, p=0.045) MS-RLS group. Multivariate regression analysis revealed Expanded Disability Status Scale spinal lesions MRI as while no impact RLS.Conclusion: Roughly quarter suffers from RLS, significantly impacting life poor sleepiness. increases with physical disability but is independent DMT.