Responses of the ischemic acute renal failure kidney to additional ischemic events

Normotensive ischemic acute renal failure.

Copyright © 2007 Massachusetts Medical Society. A cute renal failure is defined as a rapid decrease in the glomerular filtration rate, occurring over a period of minutes to days. Because the rate of production of metabolic waste exceeds the rate of renal excretion in this circumstance, serum concentrations of markers of renal function, such as urea and creatinine, rise. The causes of acute rena...

Nephron heterogeneity in ischemic acute renal failure.

To uncover the reasons for reported internephron heterogeneity in acute renal failure (ARF) serial micropuncture experiments in norepinephrine-induced ARF and sham-infused control rats were carried out to investigate this phenomenon. Proximal tubular pressures (PT) were scattered at 24, 48, and 72 hr in ARF rats ranging from 4 to 42 mm Hg, but the majority were greater than the mean control val...

Recent advances in the pathophysiology of ischemic acute renal failure.

As covered in the preceding sections, acute renal failure (ARF) is a syndrome associated with high mortality in humans. Current therapy is limited to supportive measures and preventive strategies, none of which have been definitively shown to alter mortality. Ischemic ARF is often associated with multiple organ failure and sepsis. Despite the complexity of multi-organ illness, the presence of A...

Evaluating the effect of short ischemic periods on subsequent rat renal ischemic injury

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...

Oxidative and Nitrosative Stress in the Ischemic Acute Renal Failure