Response: validity of evidence demonstrating efficacy of extracorporeal photochemotherapy
نویسندگان
چکیده
منابع مشابه
Molecular aspects of extracorporeal photochemotherapy.
8-methoxypsoralen (8-MOP), activated upon exposure to long-wavelength ultraviolet radiation, is used therapeutically to treat the diseased blood cells of cutaneous T-cell lymphoma patients. The factors responsible for the efficacy of this therapy are reviewed. Primary among these are the plasma level of 8-MOP at the time of irradiation and the effective dose of UVA. 8-MOP plasma levels determin...
متن کاملEngineering aspects of extracorporeal photochemotherapy.
Photopheresis is a new extracorporeal photochemotherapy in which the patient's blood or certain blood fraction is exposed to light in the presence of a light-activatable drug. The major engineering elements involved for better system design and patient treatment, such as system model, cell separation, irradiation, and energy measurement, are discussed.
متن کاملExtracorporeal photochemotherapy for generalized deep morphea.
Ten years ago, a 49-year-old white patient presented with a reticulated erythema and induration of her abdominal skin. Over the next 5 years, the erythema and induration progressed to include the skin over her lower extremities, chest, back, and upper extremities. With the onset of new lesions, she frequently experienced pruritus and tenderness at the areas of involvement. She also noted decrea...
متن کاملRapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy.
Extracorporeal photochemotherapy (ECP) is widely used to treat cutaneous T-cell lymphoma, graft-versus-host disease, and allografted organ rejection. Its clinical and experimental efficacy in cancer immunotherapy and autoreactive disorders suggests a novel mechanism. This study reveals that ECP induces a high percentage of processed monocytes to enter the antigen-presenting dendritic cell (DC) ...
متن کاملExtracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD.
Chronic graft-versus-host disease (GVHD) is a major limitation of successful allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal photochemotherapy (ECP) has been tested extensively in small cohorts of patients with chronic GVHD. In this study, we retrospectively evaluated 71 patients with severe chronic GVHD treated with ECP. Response rate was 61% (n = 43), and 14 patients...
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ژورنال
عنوان ژورنال: Blood
سال: 2011
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2010-11-317107