Response to Yang and Chan. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665-2673
نویسندگان
چکیده
منابع مشابه
Response to Yang and Chan. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
Y ang and Chan (1) express uncertainty regarding immortal time bias, an established and rigorously founded principle in epidemiology and statistical sciences, and use data from the Hong Kong Diabetes Registry to quantify the effect of statin use on cardiovascular outcomes. Using the time-fixed approach, known to introduce immortal time bias, they find that statin use is associated with a 34% re...
متن کاملResponse to Bodmer et al. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
In the comment by Bodmer et al. (1), the authors question our assertion that several of their studies suffered from time-window bias (2). Perhaps there are subtleties about this bias that need to be further clarified. In the authors’ breast cancer study (3), cases and controls were matched on age, sex (although all females), general practice, and index date (i.e., the calendar date of the breas...
متن کاملComment on: Suissa and Azoulay. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
We agree with Suissa and Azoulay (1) that observational studies, particularly those of drug effects, can be subject to biases and that “timerelated” biases must be carefully controlled in these types of studies. In their recently published article (1), Suissa and Azoulay have attempted to “show that several of the observational studies investigating the association between metformin and cancer ...
متن کاملComment on: Suissa and Azoulay. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
In a recent article in Diabetes Care, Suissa and Azoulay (1) concluded that the impressive results of the metformin-associated reduced cancer risk were due to many researchers failing to adjust for immortal time bias and not using time-dependent analysis of drug exposure. However, this conclusion is not justified since it remains controversial whether immortal time would introduce substantial b...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes Care
سال: 2013
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc13-0133