Respiratory Infections: Do We Ever Recover?

Tissue concentrations: do we ever learn?

Over the last decades, numerous papers have appeared--and still are appearing--that describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent based on these concentrations and MICs for microorganisms. A common method is to use measurements of concentrations in tissue homogenates, comparing these with values derived from the corresponding blood samples and...

Protein binding: do we ever learn?

Although the influence of protein binding (PB) on antibacterial activity has been reported for many antibiotics and over many years, there is currently no standardization for pharmacodynamic models that account for the impact of protein binding of antimicrobial agents in vitro. This might explain the somewhat contradictory results obtained from different studies. Simple in vitro models which co...

Do We Ever Really Get out of Anarchy?"

A major point of dispute among libertarian theorists and thinkers today as always revolves around the age-old question of whether man can live in total anarchy or whether the minimal state is absolutely necessary for the maximization of freedom. Lost in this dispute is the question of whether man is capable of getting out of anarchy at all. Can we really abolish anarchy and set up a Government ...

Do alcoholics recover?

cataract surgery in the same hands. Rehabilitation is much easier than with other methods. The postoperative vision and orientation seem natural, and the patient can often see well without an additional optical correction. With this technique cataract surgery can be offered to patients with unilateral lens opacities which used to be left untreated when the fellow eye remained unaffected. Provid...

Do We Know What We Do not Know? A Response to Celine Bonnet