Respiratory and muscular dysfunction of the respiratory muscles and chronic obstructive pulmonary disease: pathophysiological relationships and clinical significance
نویسندگان
چکیده
The review presents literature data on the problem of respiratory muscle (RM) dysfunction in patients with chronic obstructive pulmonary disease (COPD). main features their pathophysiological interactions and clinical practice values were observed. Both local systemic factors pathogenesis COPD are important development RM dysfunction. Local associated lung remodeling need to overcome excessive breathing resistance, which increases intensity work, contributes hypertrophy insufficiency. Chronic inflammation, oxidative stress, proteolysis other manifestations change metabolism, structural functional organization RM. severity morpho-functional disorders metabolic status depends gravity emerges early stages as myocytes’ hypertrophy, increasing capillarization mitochondrion density. At late it appears diffuse replacement fibers by connective tissue. Low nutritional status, protein-energy deficiency, electrolyte imbalance, endocrine background progressive insufficiency tissue hypoxia contribute weakness. combination COPD, acute cerebral circulation heart failure sharply worsens function prognosis comorbid diseases. Also, having is significantly aggravated at age senility. discusses possibilities pharmacological correction aspects this problem.
منابع مشابه
Overlap Syndrome in Respiratory Medicine: Asthma and Chronic Obstructive Pulmonary Disease
Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. However, the distinction between the two obstructive diseases is not always clear. Multiple epidemiological studies demonstrate that in elderly people with o...
متن کاملThe Respiratory Muscles in Chronic Obstructive Pulmonary Disease Respiratory muscle function and activation in chronic obstructive pulmonary disease
McKenzie DK, Butler JE, Gandevia SC. Respiratory muscle function and activation in chronic obstructive pulmonary disease. J Appl Physiol 107: 621–629, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.00163.2009.— Inspiratory muscles are uniquely adapted for endurance, but their function is compromised in chronic obstructive pulmonary disease (COPD) due to increased loads, reduced ...
متن کاملThe respiratory muscles in chronic obstructive pulmonary disease.
McKenzie DK, Butler JE, Gandevia SC. Respiratory muscle function and activation in chronic obstructive pulmonary disease. J Appl Physiol 107: 621–629, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.00163.2009.— Inspiratory muscles are uniquely adapted for endurance, but their function is compromised in chronic obstructive pulmonary disease (COPD) due to increased loads, reduced ...
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ژورنال
عنوان ژورنال: ????????????? ??????????? ??????
سال: 2022
ISSN: ['1990-9780']
DOI: https://doi.org/10.34215/1609-1175-2022-1-17-25