Resonance in the Chloroacetic Acids

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Effect of chloroacetic acids on the kidneys.

The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumption. Renal phosphate-dependent glutaminase activity was increased at the highest concentration, an...

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ژورنال

عنوان ژورنال: Nature

سال: 1940

ISSN: 0028-0836,1476-4687

DOI: 10.1038/145625a0