Resolution of danazol-induced cholestasis with S-adenosylmethionine.
نویسندگان
چکیده
منابع مشابه
Resolution of danazol-induced cholestasis with S-adenosylmethionine.
In a case of danazol-induced cholestasis, the anti-cholestatic agent S-adenosylmethionine was given intravenously for 3 weeks and then orally for 6 weeks. This was well tolerated and led to prompt resolution of both jaundice and associated renal impairment.
متن کاملEffect of S-adenosylmethionine on total parenteral nutrition-associated cholestasis
Methods: Twenty-four newborn rabbits were randomly divided into 3 groups: normal control group receiving breast milk, TPN group receiving TPN at a dose of 200 kcal/kg per day, and SAMe group receiving TPN plus SAMe at an intravenous dose of 100 mg/kg per day. Blood and liver samples were collected one week later. The levels of serum bile acid, alanine aminotransferase (ALT), alkaline phosphatas...
متن کاملUrsodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis
CONTEXT An optimal therapeutic strategy has not yet been identified for the pharmacological treatment of intrahepatic cholestasis of pregnancy (ICP). The aim of this study was to evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) in the treatment of ICP, both individually and in combination. EVIDENCE ACQUISITION A meta-analysis of all randomized co...
متن کاملursodeoxycholic acid and s-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy: a meta-analysis
conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...
متن کاملS-Adenosylmethionine and methylation.
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells. S-Adenosylhomocysteine (AdoHcy), formed after donation of the methyl group of AdoMet to a methyl acceptor, is then hydrolyze...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1993
ISSN: 0032-5473
DOI: 10.1136/pgmj.69.809.237