منابع مشابه
Resistance of influenza viruses to neuraminidase inhibitors--a review.
Influenza virus is a negative stranded RNA virus. It contains two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). HA exists as a trimer and is responsible for binding to the terminal sialic acid bound to receptors on the surface of the target cell, leading to attachment and subsequent penetration by the virus into the cell. Influenza virus isolates from different animals appea...
متن کاملSystematic review of influenza resistance to the neuraminidase inhibitors
BACKGROUND Antivirals play a critical role in the prevention and the management of influenza. One class of antivirals, neuraminidase inhibitors (NAIs), is effective against all human influenza viruses. Currently there are two NAI drugs which are licensed worldwide: oseltamivir (Tamiflu®) and zanamivir (Relenza®); and two drugs which have received recent approval in Japan: peramivir and laninami...
متن کاملGlobal assessment of resistance to neuraminidase inhibitors, 2008-2011: the Influenza Resistance Information Study (IRIS).
BACKGROUND Following emergence of naturally occurring oseltamivir-resistant influenza A(H1N1) viruses, a global observational investigation, the Influenza Resistance Information Study (IRIS; NCT00884117), was initiated in 2008 to study neuraminidase inhibitor (NAI) resistance and clinical outcome. METHODS Patients with influenza-like illness and/or positive rapid test results agreed to swabs ...
متن کاملInfluenza neuraminidase inhibitors: antiviral action and mechanisms of resistance
There are two major classes of antivirals available for the treatment and prevention of influenza, the M2 inhibitors and the neuraminidase inhibitors (NAIs). The M2 inhibitors are cheap, but they are only effective against influenza A viruses, and resistance arises rapidly. The current influenza A H3N2 and pandemic A(H1N1)pdm09 viruses are already resistant to the M2 inhibitors as are many H5N1...
متن کاملInfluenza viruses resistant to neuraminidase inhibitors.
Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detecte...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2011
ISSN: 1537-6591,1058-4838
DOI: 10.1093/cid/ciq184