Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge
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چکیده
منابع مشابه
Circadian Gene Expression in the Suprachiasmatic Nucleus 901 Circadian Gene Expression in the Suprachiasmatic Nucleus
Regulated expression of a core set of clock genes is the basis of circadian timekeeping in vertebrates, as in other organisms. Clock genes are defined as being necessary to generate normal circadian rhythms, near 24 h oscillations in biological processes. With the enlargement of the brain in vertebrates, control of circadian rhythms became centralized. In lower vertebrates, such as fishes, liza...
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The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal circadian pacemaker of the brain. It co-ordinates the daily rhythms of sleep and wakefulness, as well as physiology and behaviour, that set the tempo to our lives. Disturbance of this daily pattern, most acutely with jet-lag but more insidiously with rotational shift-work, can have severely deleterious effects for mental fun...
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The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genoty...
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The circadian clock system adapts phasic physiological activities, such as sleeping and eating, to environmental cycles. The “master clock” is in the suprachiasmatic nucleus (SCN) and the principal cue (Zeitgeber) is the light–dark cycle, around which most mammalian (and those of all living organisms) functions have evolved. In our society, with activity 24 h per day, the clock is frequently ov...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2016589117