Researches and applications of nitroimidazole heterocycles in medicinal chemistry

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Siderophore and Its Applications in the Field of Bioenvironmental Researches

Iron, one of the essential micronutrients, is needed for electron transport and metabolic processes in almost all living organisms. The ferric form (Fe3+) of iron is insoluble in nature and inaccessible at physiological pH (7.35–7.40). Under iron-limited conditions, metal-chelating agents such as siderophores are synthesized by many bacteria and a few fungi. Siderophores have a high affinity fo...

متن کامل

Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry.

Gold-catalyzed transformations allow efficient access to a wide scope of heterocyclic structures that serve as building blocks and pharmacophores in medicinal chemistry. Compared with other transition metal and Lewis acid catalysis, gold catalysis presents mechanistic divergence, excellent functional group tolerance and/or operational advantages. Emergent applications of gold catalysis have pla...

متن کامل

Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.

In recent years, there has been an ever-increasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from modern biological screening techniques. The present review describes one of these reactions, the 1,3-dipolar cycloa...

متن کامل

Drug design, biotechnology and medicinal chemistry: applications to infectious diseases

current drug design strategies are based on the understanding of the physio-pathology of diseases, biochemical pathways and selection of molecular targets. Modernbiotechnological tools have provided valuable information to facilitate the discovery ofnew drug candidates. Medicinal chemistry has a vital role in a variety of processes aimedat the identification of bioactive substan...

متن کامل

Fluorine in medicinal chemistry.

Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and pharmacokinetics. This review will highlight the special n...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: SCIENTIA SINICA Chimica

سال: 2018

ISSN: 1674-7224

DOI: 10.1360/n032018-00098