منابع مشابه
RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
RES-529 (previously named Palomid 529, P529) is a phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) pathway inhibitor that interferes with the pathway through both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) dissociation. This compound is currently being developed in oncology and ophthalmology. The oncology focus is for the treatment of glioblastoma, where it h...
متن کاملDev129957 516..529
Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic and hindbrain serotonergic pathways controlling motivation, mood, and voluntary movements. Such neurons reside both within the dopaminergic nuclei, and in adjacent brain structures, including the rostromedial and laterodorsal tegmental nuclei. Compared with the monoaminergic neurons, the deve...
متن کامل#529 - Toxics Affect Behavior
The toxic metal, lead, is associated with aggressive behavior, delinquency, and attention disorders in boys between the ages of 7 and 11, according to a study by Herbert Needleman published in 1996 in the JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA).[1] Aggressive behavior, delinquency and attention disorders in youth are, themselves, predictors of criminal behavior later in life.[2] This...
متن کاملDmd054718 529..536
The UDP-glucuronosyltransferase (UGT) 2B subfamily of enzymes plays an important role in the metabolism of numerous endogenous and exogenous compounds, including various carcinogens present in tobacco smoke. The goal of the present study was to examine the levels of expression of individual UGT2B genes in various tissues that are targets for tobacco carcinogenesis. Using MTATP6 as the experimen...
متن کاملNpgrj_ng_129 529..537
Jan Monti1,2,9, Judith Fischer1,9, Svetlana Paskas1, Matthias Heinig1,3, Herbert Schulz1, Claudia Gösele1, Arnd Heuser1,2, Robert Fischer1,2, Cosima Schmidt1, Alexander Schirdewan2, Volkmar Gross1, Oliver Hummel1, Henrike Maatz1, Giannino Patone1, Kathrin Saar1, Martin Vingron3, Steven M Weldon4, Klaus Lindpaintner5, Bruce D Hammock6, Klaus Rohde1, Rainer Dietz1,2, Stuart A Cook7, Wolf-Hagen Sc...
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ژورنال
عنوان ژورنال: Anti-Cancer Drugs
سال: 2016
ISSN: 0959-4973
DOI: 10.1097/cad.0000000000000354