Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass
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منابع مشابه
Tadalafil in the treatment of erectile dysfunction
The treatment for erectile dysfunction (ED) was revolutionized with the development of phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil (Cialis((R)); Eli Lilly and Company, Indianapolis, IN, USA) is the newest and most versatile PDE5 inhibitor in the clinical armamentarium for the treatment of ED. Its most unique characteristic is its long half-life of 17.5 hours, which lends itself to a l...
متن کاملPatient preference and satisfaction in erectile dysfunction therapy: a comparison of the three phosphodiesterase-5 inhibitors sildenafil, vardenafil and tadalafil
Erectile dysfunction (ED) is a problem that may affect up to 52% of men between the ages of 40 and 70. It can be distressing because of its negative effect on self-esteem, quality of life, and interpersonal relationships. Oral phosphodiesterase-5 inhibitors (PDE5 inhibitors) are now the first choice of treatment in ED. The availability of three (sildenafil citrate, tadalafil, and vardenafil) we...
متن کاملVardenafil – A new and effective treatment for erectile dysfunction
Vardenafil (Levitra, Bayer Healthcare/GlaxoSmithKline, USA) is a phosphodiesterase 5 inhibitor developed specifically for use as an oral therapy for erectile dysfunction (ED). This review provides an overview of recent clinical trial results that support the use of this compound as first-line therapy in patients with ED. Specifically, data from clinical trials performed in multiple countries ha...
متن کاملVardenafil in Erectile Dysfunction: The Evidence of Its Therapeutic Value
Erectile dysfunction (ED) is a condition that affects approximately 18 million American men. Phosphodiesterase-5 inhibitors (PDE5i’s) have revolutionized the treatment of erectile dysfunction by providing the first highly-effective oral medication. Vardenafil is one of 3 PDE5i’s commercially available for the treatment of ED in the United States. It has demonstrated therapeutic efficacy in the ...
متن کاملVardenafil: a review of its use in erectile dysfunction.
UNLABELLED Vardenafil (Levitra) is a potent and highly selective oral phosphodiesterase type 5 (PDE5) inhibitor. Vardenafil improved erectile function in men with mild to severe erectile dysfunction (ED) of varying aetiology in two randomised, double-blind, multicentre, fixed-dose studies of 12 or 26 weeks' duration. Men receiving vardenafil 10 or 20 mg had significantly greater improvements in...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2000950117