Reprogramming tumor-immune cell communication with a radiosensitive nanoregulator for immunotherapy

Modulating tumor-associated macrophages from tumor-promoting M2 to tumoricidal M1 phenotype is promising for anti-tumor immunotherapy but remains challenging, especially in a controllable manner. Herein, we report radiosensitive nanoregulator (AuDAP) activatable immunotherapy. AuDAP can simultaneously recognize and bind with tumor cells by polyvalent interactions. Under low-dose medical X-ray irradiation, the could generate reactive oxygen species (ROS) activate nuclear factor kappa-B (NF-κB) signaling pathway repolarize into phenotype, thereby activating immune function of situ. A series vitro vivo experiments demonstrated cell communication remodeling activation effects AuDAP. As result, + inhibited growth tumors effectively prevented their metastasis during long period observation. This may serve as nanomedicine precise therapy, this work offers new insights