Reply: Y-chromosome microdeletions are not associated with SHOX haploinsufficiency
نویسندگان
چکیده
منابع مشابه
Y-chromosome microdeletions are not associated with SHOX haploinsufficiency.
STUDY QUESTION Are Y-chromosome microdeletions associated with SHOX haploinsufficiency, thus representing a risk of skeletal anomalies for the carriers and their male descendents? SUMMARY ANSWER The present study shows that SHOX haploinsufficiency is unlikely to be associated with Y-chromosome microdeletions. WHAT IS KNOWN ALREADY Y-chromosome microdeletions are not commonly known as a majo...
متن کاملO-7: Y Chromosome Microdeletions Are Not Associated with Spontaneous Recurrent Pregnancy Loss in A Sinhalese Population in Sri Lanka
Background: Many advances have been made in reproductive medicine yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared to the general population, a higher frequency of spontaneous...
متن کاملLETTERS TO THE EDITOR Y-chromosomemicrodeletions are not associated with SHOX haploinsufficiency
Dear Sir, Dr Chianese et al. (2013) expressed concerns about their results reported in ‘Y-chromosome microdeletions are not associated with SHOX haploinsufficiency’ and our earlier publication ‘Aberrations in pseudoautosomal regions (PARs) found in infertile men with Y-chromosome microdeletions’ (Jorgez et al., 2011). We wish to respond to several of their statements regarding our work in hopes...
متن کاملY chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka.
BACKGROUND Many advances have been made in reproductive medicine, yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in ∼7% of men with low sperm counts and, compared with the general population, a higher frequency of spontaneous pregnancy ...
متن کامل[Y chromosome microdeletions in male infertility].
A genetic basis of infertility may exist in many men currently classified as having idiopathic infertility. Approximately 7% of infertile men harbour submicroscopic deletions of the Y chromosome that are not detectable on routine karyotype. Two candidate gene families, namely the RNA-binding motif-containing gene family, and the deleted-in-azoospermia gene family, have been cloned by deletion m...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2014
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/deu037