Reply to TR Hill and I Kyriazakis

Reply to TR Fenton

I agreewith Fenton and Fenton that the current evidence on the paleo diet might be considered early or preliminary and that further research is critically needed. There is a risk of great societal harm if dietary guidelines and recommendations are issued without a strong foundation of evidence from methodologically robust randomized controlled trials (RCTs), ideally trials comparing different d...

A painful TR(i)P to lysosomes

The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca2+ to trigger vesicle exocytosis and neuropeptide release.

Reply to I. Petropavlovskikh’s interactive comment

Tasty and healthy TR(i)Ps

For the majority of the developed world, the hunter–gatherer lifestyle that served our predecessors for millennia is a distant memory. yet, despite our increasingly sophisticated approach to food as top chefs compete for Michelin stars, our basic ability to taste chemical signatures and perceive flavour has not changed. in fact, in addition to sight, the ability to taste might have been one of ...

Activities of Chloroplast Fragments I . HILL REACTION

Hill activity with ferricyanide and nicotinamide adenine dinucleotide phosphate and photoreduction of NADP and methyl red supported by ascorbate and 2,6-dichloroindophenol were studied as a function of the size of chloroplast fragments. Sonic treatment of chloroplasts resulted in a decrease in Hill activity with NADP and ferricyanide. The decrease was accompanied by a change in the dependency o...