Reply: Quantitative evaluation of the human subventricular zone

LETTER TO THE EDITOR Reply: Quantitative evaluation of the human subventricular zone

1 Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience (NIN), An Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands 2 Department of Neuroregeneration, NIN, An institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands 3 Department of Anatomy and Neurosciences, Secti...

LETTER TO THE EDITOR Quantitative evaluation of the human subventricular zone

1 German Centre for Neurodegenerative Diseases (DZNE), Munich, D-81677 Munich, Germany 2 Department of Neurology, Technical University Munich, D-81377 Munich, Germany 3 Department of Neurology, Philipps University, D-35033 Marburg, Germany 4 Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK 5 Kentucky Spinal Cord Injury Resea...

Subventricular Zone Cell Migration: Lessons from Quantitative Two-Photon Microscopy

Neuroblasts born in the adult subventricular zone (SVZ) migrate long distances in the rostral migratory stream (RMS) to the olfactory bulbs where they integrate into circuitry as functional interneurons. As very little was known about the dynamic parameters of SVZ neuroblast migration, we used two-photon time-lapse microscopy to analyze migration in acute slices. This involved analyzing 3D stac...

Proliferation in the human ipsilateral subventricular zone after ischemic stroke

Neonatal subventricular zone electroporation.

Neural stem cells (NSCs) line the postnatal lateral ventricles and give rise to multiple cell types which include neurons, astrocytes, and ependymal cells. Understanding the molecular pathways responsible for NSC self-renewal, commitment, and differentiation is critical for harnessing their unique potential to repair the brain and better understand central nervous system disorders. Previous met...