Replication Protein A Unfolds G-Quadruplex Structures with Varying Degrees of Efficiency
نویسندگان
چکیده
منابع مشابه
Human replication protein A unfolds telomeric G-quadruplexes
G-quadruplex structures inhibit telomerase activity and must be disrupted for telomere elongation during S phase. It has been suggested that the replication protein A (RPA) could unwind and maintain single-stranded DNA in a state amenable to the binding of telomeric components. We show here that under near-physiological in vitro conditions, human RPA is able to bind and unfold G-quadruplex stru...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2012
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp300546u