Replication: DNA Building Block Synthesis On Demand

Replication: DNA Building Block Synthesis On Demand

Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

DNA replication: Building the perfect switch

A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

Building up the machinery for DNA replication.

DNA REPLICATION AND SYNTHESIS OF DNABINDING PROTEINS IN THE CHLOROPLASTS OF A CALLUS CULTURE

Continuous labelling of callus with H-thymidine results in intermittent peaks of H-DNA per chloroplast, showing synchrony of division. The increase in H-DNA could be due to several replication rounds, and the drop to successive plastid divisions without intervening DNA synthesis. The level of DNA-binding proteins in the chloroplast parallels the peaks of plastidal DNA synthesis; such pro...

Building video-on-demand servers

Toward the direction of supporting an end-to-end video-on-demand (VOD) system with guaranteed quality over ATM networks, this paper introduces our eeorts to solve this challenging problem from the source: building VOD servers. One of the performance objectives of building VOD servers is to support the maximum number of concurrent video streams with acceptable quality of services (e.g., guarante...