Replacing bad (F)actors: hemophilia

Acetate-replacing Factors for Lactic Acid Bacteria

The stimulatory effect of sodium acetate on growth of lactic acid bacteria was first demonstrated by Snell et al. (1). Guirard et al. (2) investigated the role of acetate in the nutrition of certain lactic acid bacteria and showed that acetate serves a dual purpose in media, (a) that of a buffer and (b) that of a probable precursor of various lipides. It was further demonstrated (3) that some b...

Bioengineering coagulation factors for improved hemophilia treatments☆

The implementation of prophylaxis with regular factor VIII (FVIII) replacement for patients with hemophilia radically changed the clinical presentation of this condition, from a disease characterized by progressive disabling musculoskeletal complications, to one compatible with an active and virtually normal lifestyle. In Brazil, although most adults with severe hemophilia still suffer the impa...

Replacing reprogramming factors with antibodies selected from autocrine antibody libraries

Prevalence and risk factors for hypertension in hemophilia.

Hypertension (HTN) is a major risk factor for intracranial hemorrhage. We, therefore, investigated the prevalence, treatment, and control of HTN in adult patients with hemophilia (PWH). PWH≥18 years (n=458) from 3 geographically different cohorts in the United States were evaluated retrospectively for HTN and risk factors. Results were compared with the nationally representative sample provided...

Factors influencing readmission after pancreaticoduodenectomy: is there a list of bad and very bad?