Repetitive transcranial magnetic stimulation (rTMS) for complex regional pain syndrome (CRPS)

Abstract Background: Complex regional pain syndrome (CRPS) is a chronic condition occurring after trauma, even minor injuries. CRPS can be difficult to diagnose and treat, its pathophysiology incompletely understood. Diagnosis of based on history clinical examination. It clinically divided in 1 (no nerve injury) 2 (with injury). Neuroplastic reorganization within the sensorimotor cortex associated aggravates CRPS, leading secondary motor symptoms apraxia/neglect similar stroke, as well possible spread additional extremities. Repetitive transcranial magnetic stimulation (rTMS) use for e.g. neuropathic pain, stroke rehabilitation, depression. Neuronavigated rTMS utilizing estimation induced electrical field (E-field) improves efficacy depression, but it has not been studied patients. The optimal cortical target site(s) protocol are neither known. Objectives: To study E-field-navigated with new targeted right parietal operculum function patients acute long-term maintenance therapy compared sham stimulation. pathophysiological mechanisms patient characteristics influencing rTMS-treatment results. Methods: In this prospective, randomized, placebo-controlled parallel group trial, we therapeutic effects 3-month follow-up at Turku Helsinki University Hospitals. Patients underwent examinations before 10-session serial treatment. Neurophysiological tests, mood, sleep were assessed baseline during follow-up. Results: 71 recruited, 62 participated. Sixty one-month control treatment period. Of these 45 had 15 2. results comparing active will analyzed repeated measures ANOVA, presented poster. Research Category Technology Methods Clinical Research: 10. Transcranial Magnetic Stimulation (TMS) Keywords: (rTMS), E-field navigation,