Repeated recall and PKMζ maintain fear memories in juvenile rats
نویسندگان
چکیده
منابع مشابه
PKMζ contributes in consolidation, retrieval and maintenance of amygdala dependent fear memory in rats
Introduction: Protein kinase M zeta (PKMζ) is assumed to be actively involved in retainig long-term potentiation. The goal of this study was to investigate the role of PKMζ in basolateral amygdala (BLA) upon acquisition, consolidation, retention and retrieval of memory using a specific inhibitor of PKMζ. Methods: Sixty male wistar rats underwent stereotaxic surgery and were cannu...
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How long-term memories are stored is a fundamental question in neuroscience. The first molecular mechanism for long-term memory storage in the brain was recently identified as the persistent action of protein kinase Mzeta (PKMzeta), an autonomously active atypical protein kinase C (PKC) isoform critical for the maintenance of long-term potentiation (LTP). PKMzeta maintains aversively conditione...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2016
ISSN: 1549-5485
DOI: 10.1101/lm.042549.116