Repeat length variations in polyglutamine disease-associated genes affect body mass index
نویسندگان
چکیده
منابع مشابه
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Amino-terminal fragments of huntingtin, which contain the expanded polyglutamine repeat, have been proposed to contribute to the pathology of Huntington's disease (HD). Data supporting this claim have been generated from patients with HD in which truncated amino-terminal fragments forming intranuclear inclusions have been observed, and from animal and cell-based models of HD where it has been d...
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Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. Methods. We studied 1423 children aged 6-12 years. ...
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The nuclear receptor coactivator 3 (NCOA3) is a protein that binds to nuclear hormone receptors and thereby facilitates the expression of downstream genes. The NCOA3 gene has been found to be overexpressed in breast tumors (1). On exon 21, the NCOA3 gene contains a polymorphic region with a trinucleotide repeat encoding a polyglutamine repeat in the COOH terminus of the NCOA3 protein. Longer re...
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INTRODUCTION The Body Mass Index (BMI) quantifies nutritional status and classifies humans as underweight, of normal weight, overweight, mildly obese, moderately obese or morbidly obese. Obesity is the excessive accumulation of fat, defined as BMI higher than 30 kg/m2. Obesity is widely accepted to complicate anaesthesia and surgery, being a risk factor for mediastinitis after coronary artery b...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2018
ISSN: 0307-0565,1476-5497
DOI: 10.1038/s41366-018-0161-7