منابع مشابه
Influence of 5-HT1A and 5-HTTLPR genetic variants on the schizophrenia symptoms and occurrence of treatment-resistant schizophrenia
This study aimed to explore the influence of two genetic polymorphisms of the 5-hydroxytryptamine 1A receptor (5-HT1A) and solute carrier family 6, member 4 (SLC6A4) genes on the clinical symptoms and treatment resistance in Slovenian patients with schizophrenia. A total of 138 patients with schizophrenia were evaluated using the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Sc...
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BACKGROUND Alterations of serotonin neurotransmission are implicated in both mood disorders and schizophrenia. Specific serotonin-receptor-based abnormalities in these psychiatric illnesses have been intensively studied; however, it has been difficult to draw any conclusions because of a lack of consensus. These inconsistencies have most likely arisen from the unavailability of selective ligand...
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متن کامل5-HT3 antagonist for cognition improvement in schizophrenia: a double blind, placebo-controlled trial
Introduction: Patients with schizophrenia characteristically exhibit cognitive deficits. The level of cognitive impairment is found to predict the functional outcome of the illness more strongly than the severity of positive or negative symptoms. The purpose of this study was to assess the efficacy of ondansetron, a 5-HT3 receptor antagonist as an adjuvant agent in the treatment of chronic...
متن کاملPolymorphic Variations in 5-HT2A, 5-HTT and DISC 1 in First Episode Schizophrenia Patients
Introduction Schizophrenia is a severe psychotic disorder characteristically marked by a retreat from reality with delusion formation, hallucinations, emotional disharmony, and regressive behaviour. Affecting approximately 1% of the worldwide population and is associated with a high rate of morbidity and mortality. Studies suggest that genetics, early environment, neurobiology and psychological...
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ژورنال
عنوان ژورنال: Epidemiology and Psychiatric Sciences
سال: 2018
ISSN: 2045-7960,2045-7979
DOI: 10.1017/s2045796018000586