Renal Vascular Function in Hypercholesterolemia Is Preserved by Chronic Antioxidant Supplementation
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چکیده
منابع مشابه
Coronary endothelial function is preserved with chronic endothelin receptor antagonism in experimental hypercholesterolemia in vitro.
Hypercholesterolemia is associated with increased circulating and tissue endothelin-1 immunoreactivity, decreased nitric oxide (NO) activity, and altered endothelial function. We tested the hypothesis that chronic endothelin receptor antagonism preserves endothelial function and increases NO in experimental porcine hypercholesterolemia. Pigs were randomized to 3 groups: Group 1, a 2% high-chole...
متن کاملIn vivo renal vascular and tubular function in experimental hypercholesterolemia.
Hypercholesterolemia (HC) is often associated with impaired peripheral and coronary vascular responses to endothelium-dependent vasodilators, which are probably due to low bioavailability of nitric oxide. To examine the effect of HC on renal vascular and tubular function, 22 domestic pigs were studied after being fed a 12-week normal (n=11) or HC (n=11) diet. Renal regional perfusion and intrat...
متن کاملVascular function in rats with adenine-induced chronic renal failure.
The aim of the present study was to characterize the function of resistance arteries, and the aorta, in rats with adenine-induced chronic renal failure (A-CRF). Sprague-Dawley rats were randomized to chow with or without adenine supplementation. After 6-10 wk, mesenteric arteries and thoracic aortas were analyzed ex vivo by wire myography. Plasma creatinine concentrations were elevated twofold ...
متن کاملErythropoietin is reduced by combination of diuretic therapy and RAAS blockade in proteinuric renal patients with preserved renal function.
BACKGROUND Renin-angiotensin-aldosterone system (RAAS) blockade improves prognosis in renal patients, but usually requires diuretic co-treatment. RAAS blockade can decrease erythropoietin (EPO) and/or haemoglobin (Hb) levels. Diuretics decrease EPO in rodents, but their effect on EPO and Hb in humans is unknown. METHODS Proteinuric renal patients with preserved renal function were treated dur...
متن کاملAntioxidant vitamins in chronic renal failure
Reactive oxygen species (ROS) play a significant role in pathogenesis of chronic renal failure (CRF) , leading to damage to protein, lipid and DNA.. The present paper focuses on the extent of free radical damage on lipid (measured as malondialdehyde, MDA) and effect on antioxidant defense mechanism (measured as vitamin E and vitamin C in the serum of CRF patients predialytically. The study was ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2001
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v1291882