Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system.

[Uric acid clearance in normal and gouty subjects].

substrates and products have no effect. Fractionation of normal erythrocytes by hypotonic lysis reveals a decline in the specific activity of A-PRT as the red cells age. In patients with the Lesch-Nyhan syndrome, the decline in A-PRT activity with ageing of cells is much less marked. Furthermore, the concentrations of free PRPP are as much as 10-fold elevated in the erythrocytes of these childr...

Renal handling of uric acid in man.

The uricosuric response to 80 mg of micronized Benzbromarone was employed to assess the renal tubular secretory site for uric acid in patients with primary gout. Since Benzbromarone selectively inhibits tubular reabsorption of secreted urate, the maximum uricosuria induced by this drug can be equated with the minimal secretory rate. Furthermore, a significant relationship was noted in normal co...

Association of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels

Several studies have reported that hyperuricemia is associated with the development of hypertension and cardiovascular disease. Increasing evidences also suggest that hyperuricemia may have a pathogenic role in the progression of renal disease. Paradoxically, uric acid is also widely accepted to have antioxidant activity in experimental studies. We aimed to investigate the association between g...

The effect of benemid (P-[DI-N-propylsulfamyl]-benzoic acid) on uric acid metabolism in one normal and one gouty subject.

Effects of allopurinol on gouty and non-gouty uric acid nephropathy.

The kidneys are probably the only vital organs that are commonly affected by the precipitation of uric acid in patients with gout. Microscopic crystals of uric acid can sometimes be demonstrated in the collecting tubules, along with macros^opic concretions or calculi in the medulla and pelvis (Lichtenstein, Scott, and Levin, 1956; Talbott and Terplan, 1960; Gonick, Rubini, Gleason, and Sommers,...