Renal denervation in heart failure: Modulating the sympathetic nervous system
نویسندگان
چکیده
منابع مشابه
The sympathetic nervous system and heart failure.
Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous system and abnormal responsiveness of the parasympathetic nervous system. Studies in the 1980s and 1990s demonstrated that inhibition of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors improved symptoms and mortality in HF resulting from systolic dysfunction, thus pro...
متن کاملSympathetic nervous system in heart failure.
For those who have comfortably accepted the mechanistic link between sympathetic nervous system activation and poor outcome in heart failure, the study by Brede et al1 in this issue of Circulation is a welcome confirmation. The authors appear to have demonstrated in a murine model that absence of sympathoinhibitory 2 adrenoreceptors is associated with overactive catecholamine release, aggressiv...
متن کاملTargeting the sympathetic nervous system: critical issues in patient selection, efficacy, and safety of renal denervation.
E vidence has accumulated during the past several decades, strongly suggesting that abnormalities of the sympathetic nervous system contribute to the development and maintenance of multiple disease states, including hypertension, heart failure, diabetes mellitus, sleep apnea, kidney disease, and atrial fibrilla-tion. 1 The renal nerves have been identified as important contributors to the devel...
متن کاملRenal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function.
Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery and progressed into heart failure for 4 wk before receiving bilateral RDx or sham RDx. After additional ...
متن کاملResponse to blood pressure and sympathetic nervous system response to renal denervation.
To the Editor: In contrast to several other studies, including the randomized controlled Symplicity-2 trial, renal denervation (RDN) was not associated with a blood pressure (BP) reduction in this small study by Brinkmann et al. It is noteworthy that average baseline BP was significantly lower (157±7/85±4 mm Hg) compared with baseline levels of 178±18/97±16 mm Hg in Symplicity-2, which may expl...
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ژورنال
عنوان ژورنال: Revista Portuguesa de Cardiologia
سال: 2017
ISSN: 0870-2551
DOI: 10.1016/j.repc.2016.11.003