Renal allograft rejection: sonography and scintigraphy

Mechanisms of Renal Allograft Rejection

Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...

HLA-DRw6 and renal allograft rejection.

HLA-DRw6-positive patients are "high responders" to certain renal allograft antigens. A study was therefore conducted of the outcome of 247 first renal allografts in 74 DRw6-positive and 173 DRw6-negative recipients. The effectiveness of matching for HLA-DR determinants in both groups was also analysed. The one-year graft survival in DRw6-positive patients was 59% as compared with 75% in DRw6-n...

Soluble CD30 and Acute Renal Allograft Rejection

Acute allograft pancreatitis associated with renal allograft rejection.

Acute allograft pancreatitis is common following simultaneous pancreas and kidney (SPK) transplantation with either bladder or enteric drainage w1,2x. Allograft pancreatitis may be caused by infection, bladder drainage problems, alcohol, drugs and diet w1x. Pancreatic allograft rejection, usually occurring in the context of renal allograft rejection, may cause a syndrome similar to acute allogr...

Renal allograft rejection: pieces of the puzzle.

Despite a burgeoning literature on renal allograft pathology and rejection diagnosis, there are still many aspects that remain to be resolved. In this issue of JASN, two of these vexing issues are addressed. The first is the finding of isolated arteritis in allograft biopsies, without other diagnostic evidence of acute cellor antibody-mediated rejection (AMR). The other is the identification of...