Remyelination by transplanted olfactory ensheathing cells
نویسندگان
چکیده
منابع مشابه
Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.
Olfactory ensheathing cells (OECs) are candidate cells for transplant-mediated repair of persistent demyelination in diseases such as multiple sclerosis. If this approach is to make the transition from laboratory to clinic, an important issue is the most suitable composition of the OEC transplant. Isolation of OECs involves concurrent isolation of other cell types, and specific selection techni...
متن کاملMolecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord.
Myelin-forming glial cells transplanted into the demyelinated spinal cord can form compact myelin and improve conduction properties. However, little is known of the expression and organization of voltage-gated ion channels in the remyelinated central axons or whether the exogenous cells provide appropriate signaling for the maturation of nodes of Ranvier. Here, we transplanted olfactory ensheat...
متن کاملRegeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells.
Precisely localized focal stereotaxic electrolytic lesions were made in the corticospinal tract at the level of the first to second cervical segments in the adult rat. This consistently destroyed all central nervous tissue elements (axons, astrocytes, oligodendrocytes, microglia, and microvessels) in a highly circumscribed area. In a group of these rats immediately after lesioning, a suspension...
متن کاملremyelination of the corpus callosum by olfactory ensheathing cell in an experimental model of multiple sclerosis
multiple sclerosis (ms) causes loss of the myelin sheath, which leads to loss of neurons. regeneration of myelin sheath stimulates axon regeneration and neurons’ survival. in this study, olfactory ensheathing cell (oec) transplantation is investigated to restore myelin sheath in an experimental model of ms in male mice.oecs were isolated from the olfactory mucosa of seven-day-old infant rats an...
متن کاملPhagocytosis of bacteria by olfactory ensheathing cells and Schwann cells.
Opportunistic bacterial infections of the nasal cavity could potentially lead to infection of the brain if the olfactory or trigeminal nerves are colonised. The olfactory nerve may be a more susceptible route because primary olfactory neurons are in direct contact with the external environment. Peripheral glia are known to be able to phagocytose some species of bacteria and may therefore provid...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2003
ISSN: 0003-276X,1097-0185
DOI: 10.1002/ar.b.10013