Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient
نویسندگان
چکیده
منابع مشابه
Loading of doxorubicin into liposomes by forming Mn2+-drug complexes.
A new procedure for loading doxorubicin into large unilamellar vesicles (LUVs) is characterized. It is shown that doxorubicin can be loaded into LUVs composed of sphingomyelin/cholesterol (55:45 mole/mole) in response to a transmembrane MnSO4 gradient in the absence of a transmembrane pH gradient. Complex formation between doxorubicin and Mn2+ is found to be a driving force for doxorubicin upta...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2006
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2006.05.028