Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations
نویسندگان
چکیده
منابع مشابه
Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations.
Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the alignment and stretching of constituent fibers within the vicinity of cells. As a consequence, the matrix reorganizes to form thick bundles of aligned fibers that enable force transmission over distances larger than the size of the cells. Contractile force-mediated remodeling of ECM fibers has bearing on a numb...
متن کاملDifferential remodeling of extracellular matrices by breast cancer initiating cells.
Cancer initiating cells (CICs) have been the focus of recent anti-cancer therapies, exhibiting strong invasion capability via potentially enhanced ability to remodel extracellular matrices (ECM). We have identified CICs in a human breast cancer cell line, MX-1, and developed a xenograft model in SCID mice. We investigated the CICs' matrix-remodeling effects using Second Harmonic Generation (SHG...
متن کاملNon-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation
Most tissue cells grown in sparse cultures on linearly elastic substrates typically display a small, round phenotype on soft substrates and become increasingly spread as the modulus of the substrate increases until their spread area reaches a maximum value. As cell density increases, individual cells retain the same stiffness-dependent differences unless they are very close or in molecular cont...
متن کاملEffect of Stress-Fiber Inclusion on the Local Stiffness of Cell Cytoskeleton Probed by AFM Indentation: Insights from a Discrete Network Model
In this paper, we analyze the effect of stress-fiber inclusion on the stiffness of an actin random network. To do this, use a discrete random network model to analyze the elastic response of this system in terms of apparent Young’s modulus. First, we showed that for a flat-ended cylindrical AFM indenter the total indentation force has a linear relation with the indentation depth and the indente...
متن کاملFast Propagation Predictions for HF Network Simulations
The complexity of current HF radio networks (such as the SCOPE Command HF Global Communications System) has renewed interest in techniques for efficiently simulating long-haul HF radio networks. Because the dynamic propagation effects of skywave paths are the distinguishing characteristic of HF network simulations, we need to accurately simulate the connectivity among HF stations. Predictions o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.08.029