Remember, remember the 5th of November; gunpowder, particles and smog

Remember the Protofibrils

The highly prevalent neurodegenerative diseases Alzheimer’s (AD), Parkinson’s (PD), and Amyotrophic Lateral Sclerosis (ALS) have managed to elude countless efforts directed at understanding their causative agents and pathogenesis. Each of these diseases is characterized by abnormal protein aggregation under an unknown modi operandi we have determined to illuminate. AD pathology consists of neur...

Remember the Jones Criteria?

Remember kerion celsi.

To cite: Brissos J, Gouveia C, Neves C, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-200594 DESCRIPTION A healthy 3-year-old boy presented to our emergency department with a 2-week history of inflammatory scalp lesions. Physical examination revealed diffuse erythematous lesions, with focal areas of alopecia and several pustular patches with extensi...

Acid to remember

Antibodies against a vaccine vector render T cells more susceptible to HIV-1 infection, say Perreau et al. on page 2717. Their results may help explain the failure of a recent HIV vaccine trial. The HIV-1 vaccine used in Merck's STEP trial relied on a weakened form of a common cold virus, Adenovirus 5 (Ad5), to carry bits of HIV into the body. One worry about the Ad5 vector was that widespread ...

A Cluster to Remember

Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.