Relevance to various side effect expression and blood concentration of antiepileptics, valproic acid Na in infant epileptic patients.
نویسندگان
چکیده
منابع مشابه
Comparison of Valproic acid Clearance between Epileptic Patients and Patients with Acute Mania
Objective(s) The purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (VPA) in bipolar patients in comparison with those of epileptic patients. Materials and Methods Ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. Blood samples were...
متن کاملTherapeutic Drug Monitoring of Valproic Acid in Pediatric Epileptic Patients
Therapeutic drug monitoring (TDM) or the measurement of drug concentrations in plasma, serum or blood, aims to improve clinical activity, avoid toxicity, and reduce the costs of drug treatment. Specific conditions for TDM to be reasonably applied include the availability of a validated assay, a considerable inter-individual pharmacokinetic variability, a high correlation between drug concentrat...
متن کاملApparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration
BACKGROUND Valproic acid (VPA) apparent clearance (CL) estimated from total serum concentrations is analogous in elderly and non-elderly adult patients. As drug-protein binding decreases in old age, the aim of our study was to evaluate the confounding effect of the serum albumin concentration on the VPA apparent CL in elderly patients. METHODS In 102 epileptic out-patients treated with VPA in...
متن کاملAmino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients.
In this study, spectroscopic and chromatographic evidence is presented for the identification and characterization of the metabolites, valproyl glutamate (2-propylpentanoyl glutamate, VPA-GLU) and valproyl glutamine (2-propylpentanoyl glutamine, VPA-GLN) in the urine, serum, and cerebrospinal fluid (CSF) of patients on valproic acid (VPA) therapy. Moreover, the identification of valproyl glycin...
متن کاملEffect of UGT2B7 genetic variants on serum valproic acid concentration.
OBJECTIVE To investigate the effect of UGT2B7 A268G and UGT2B7 G211T genetic polymorphism on serum drug concentration of valproic acid (VPA). METHODS Genetic polymorphisms of UGT2B7 A268G and UGT2B7 G211T were tested in 248 epileptic patients by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Data including basic information, epilepsy type, times and doses of dr...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1998
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.29.207