Relevance of Catalytic Autoantibodies to Myelin Basic Protein (MBP) in Autoimmune Disorders
نویسندگان
چکیده
منابع مشابه
Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.
Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade MBP in vitro. They also induce a decrea...
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Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting. Using purified MBP, we demonstrated the binding activity of the aptamers and we also showed the affinity of MBP for oligonucleotides of specific length. Moreover, one...
متن کاملAutoantibodies in Systemic Autoimmune Disorders
1 INOVA Diagnostics, Inc., 9900 Old Grove Road, San Diego, CA 92131-1638, USA 2Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA 3 Laboratorio di Ricerche in Immunoreumatologia, Università di Milano, Istituto Auxologico Italiano, 20095 Cusano Milanino, Italy 4 Faculty of Medicine, ...
متن کاملIntrathecal synthesis of autoantibodies to myelin basic protein in multiple sclerosis.
A solid phase radioimmunoassay was used to detect anti-myelin basic protein (MBP) antibodies in the CSF and serum of multiple sclerosis (MS) patients and controls. CSF and serum samples were assayed prior to acid hydrolysis in order to detect free anti-MBP as well as after acid hydrolysis to measure the total (free and bound) amount of antibody. An anti-MBP index controlling for serum levels as...
متن کاملSerum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
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ژورنال
عنوان ژورنال: Journal of Neurology & Neuromedicine
سال: 2018
ISSN: 2572-942X
DOI: 10.29245/2572.942x/2018/4.1199